BRD-K12867552_THM-I-94_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

326 genes differentially expressed following the BRD-K12867552_THM-I-94_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABLIM1 actin binding LIM protein 1
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY9 adenylate cyclase 9
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALAS1 5'-aminolevulinate synthase 1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BSG basigin (Ok blood group)
C14ORF132 chromosome 14 open reading frame 132
C3 complement component 3
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD3D CD3d molecule, delta (CD3-TCR complex)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDA cytidine deaminase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
ELOVL5 ELOVL fatty acid elongase 5
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCH1 GTP cyclohydrolase 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GMCL1 germ cell-less, spermatogenesis associated 1
GOLGA7 golgin A7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSN gelsolin
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HOOK2 hook microtubule-tethering protein 2
HPCAL1 hippocalcin-like 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IL17RB interleukin 17 receptor B
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
INSR insulin receptor
ITM2A integral membrane protein 2A
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KIAA0513 KIAA0513
KIAA0922 KIAA0922
LEF1 lymphoid enhancer-binding factor 1
LHFP lipoma HMGIC fusion partner
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LRRN3 leucine rich repeat neuronal 3
LTA4H leukotriene A4 hydrolase
MAB21L2 mab-21-like 2 (C. elegans)
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MGST3 microsomal glutathione S-transferase 3
MPC1 mitochondrial pyruvate carrier 1
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OPN3 opsin 3
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCZ protein kinase C, zeta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRP1B ribosomal RNA processing 1B
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORBS1 sorbin and SH3 domain containing 1
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTSSA serine palmitoyltransferase, small subunit A
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SSBP2 single-stranded DNA binding protein 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRIB2 tribbles pseudokinase 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
TUBB2B tubulin, beta 2B class IIb
VIPR1 vasoactive intestinal peptide receptor 1
VWA5A von Willebrand factor A domain containing 5A
WFS1 Wolfram syndrome 1 (wolframin)
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM12 ADAM metallopeptidase domain 12
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CALB1 calbindin 1, 28kDa
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CD58 CD58 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL5A2 collagen, type V, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
DST dystonin
DUT deoxyuridine triphosphatase
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EREG epiregulin
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXL12 F-box and leucine-rich repeat protein 12
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXE1 forkhead box E1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS2 growth arrest-specific 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLIPR1 GLI pathogenesis-related 1
GSTO1 glutathione S-transferase omega 1
HDGF hepatoma-derived growth factor
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIF23 kinesin family member 23
KRT14 keratin 14, type I
LOC100129361
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PAX2 paired box 2
PAX8 paired box 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RAD23B RAD23 homolog B (S. cerevisiae)
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCRN1 secernin 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SENP6 SUMO1/sentrin specific peptidase 6
SHCBP1 SHC SH2-domain binding protein 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPC25 SPC25, NDC80 kinetochore complex component
STAG2 stromal antigen 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFEC transcription factor EC
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGOLN2 trans-golgi network protein 2
THBS1 thrombospondin 1
TM9SF3 transmembrane 9 superfamily member 3
TNS3 tensin 3
TPBG trophoblast glycoprotein
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB1 zinc finger and BTB domain containing 1
ZWINT ZW10 interacting kinetochore protein