BRD-K12867552_THM-I-94_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

391 genes differentially expressed following the BRD-K12867552_THM-I-94_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOT7 acyl-CoA thioesterase 7
ADCY9 adenylate cyclase 9
ADGRF5 adhesion G protein-coupled receptor F5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANKRD36B ankyrin repeat domain 36B
ANKRD46 ankyrin repeat domain 46
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AVPI1 arginine vasopressin-induced 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BLNK B-cell linker
BLVRB biliverdin reductase B
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND3 cyclin D3
CD14 CD14 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CLPTM1 cleft lip and palate associated transmembrane protein 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYBB cytochrome b-245, beta polypeptide
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DMXL2 Dmx-like 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GMCL1 germ cell-less, spermatogenesis associated 1
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSDMB gasdermin B
HBB hemoglobin, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPCAL1 hippocalcin-like 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI30 interferon, gamma-inducible protein 30
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNGR1 interferon gamma receptor 1
IFT27 intraflagellar transport 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGSF6 immunoglobulin superfamily, member 6
IL10RA interleukin 10 receptor, alpha
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0040 KIAA0040
KIAA0226L KIAA0226-like
KIF5C kinesin family member 5C
LAMP3 lysosomal-associated membrane protein 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100272216 uncharacterized LOC100272216
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NDRG4 NDRG family member 4
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NTS neurotensin
OLFM1 olfactomedin 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PFKM phosphofructokinase, muscle
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PON3 paraoxonase 3
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
RNASE6 ribonuclease, RNase A family, k6
ROGDI rogdi homolog (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSAD2 radical S-adenosyl methionine domain containing 2
RTN1 reticulon 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAP29 synaptosomal-associated protein, 29kDa
SNN stannin
SPARCL1 SPARC-like 1 (hevin)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TKTL1 transketolase-like 1
TMEM176B transmembrane protein 176B
TMEM30B transmembrane protein 30B
TMEM35 transmembrane protein 35
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TYROBP TYRO protein tyrosine kinase binding protein
USP18 ubiquitin specific peptidase 18
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VSIG4 V-set and immunoglobulin domain containing 4
VSNL1 visinin-like 1
WFDC1 WAP four-disulfide core domain 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADAM12 ADAM metallopeptidase domain 12
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ANXA3 annexin A3
ANXA5 annexin A5
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CELF2 CUGBP, Elav-like family member 2
CKAP4 cytoskeleton-associated protein 4
CNN1 calponin 1, basic, smooth muscle
COL18A1 collagen, type XVIII, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCTD dCMP deaminase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DOCK10 dedicator of cytokinesis 10
DRAM1 DNA-damage regulated autophagy modulator 1
DSG2 desmoglein 2
DYNLRB1 dynein, light chain, roadblock-type 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGF epidermal growth factor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
EMX2 empty spiracles homeobox 2
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FERMT2 fermitin family member 2
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
HMGB2 high mobility group box 2
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXB2 homeobox B2
HOXB6 homeobox B6
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFITM2 interferon induced transmembrane protein 2
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KPNB1 karyopherin (importin) beta 1
KRT18 keratin 18, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LASP1 LIM and SH3 protein 1
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MCM5 minichromosome maintenance complex component 5
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MGST2 microsomal glutathione S-transferase 2
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
MOK MOK protein kinase
MTMR2 myotubularin related protein 2
MYLK myosin light chain kinase
MYOF myoferlin
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
OXTR oxytocin receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PDLIM1 PDZ and LIM domain 1
PDLIM4 PDZ and LIM domain 4
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRSS23 protease, serine, 23
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTRF polymerase I and transcript release factor
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIPK2 receptor-interacting serine-threonine kinase 2
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SALL1 spalt-like transcription factor 1
SCRN1 secernin 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMS spermine synthase
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS3 tensin 3
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRIP6 thyroid hormone receptor interactor 6
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
USP1 ubiquitin specific peptidase 1
VCAN versican
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
ZMYND11 zinc finger, MYND-type containing 11