BRD-K12502280_TG-101348_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K12502280_TG-101348_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAX BCL2-associated X protein
BST2 bone marrow stromal cell antigen 2
CCNF cyclin F
CD52 CD52 molecule
CLDN10 claudin 10
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
FAM120A family with sequence similarity 120A
FBN2 fibrillin 2
FBXO21 F-box protein 21
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPX1 glutathione peroxidase 1
GRB10 growth factor receptor-bound protein 10
H2BFS H2B histone family, member S (pseudogene)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-C major histocompatibility complex, class I, C
HOPX HOP homeobox
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAPTM4B lysosomal protein transmembrane 4 beta
LMO4 LIM domain only 4
LRRN3 leucine rich repeat neuronal 3
MYRF myelin regulatory factor
NEB nebulin
NEFH neurofilament, heavy polypeptide
PEG10 paternally expressed 10
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCI protein kinase C, iota
RPL38 ribosomal protein L38
RRAGD Ras-related GTP binding D
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SSBP2 single-stranded DNA binding protein 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TBC1D31 TBC1 domain family, member 31
TNPO1 transportin 1
TOR1A torsin family 1, member A (torsin A)
UBE2S ubiquitin-conjugating enzyme E2S
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACTN1 actinin, alpha 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ANO1 anoctamin 1, calcium activated chloride channel
APOD apolipoprotein D
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C1ORF54 chromosome 1 open reading frame 54
C1S complement component 1, s subcomponent
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL8 chemokine (C-C motif) ligand 8
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DENND2D DENN/MADD domain containing 2D
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNA1 ephrin-A1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
IDO1 indoleamine 2,3-dioxygenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL7R interleukin 7 receptor
INHBA inhibin, beta A
IPO13 importin 13
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA1324 KIAA1324
KLF10 Kruppel-like factor 10
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LUM lumican
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
PLIN1 perilipin 1
PRKCD protein kinase C, delta
PROM1 prominin 1
QDPR quinoid dihydropteridine reductase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS2 sorbin and SH3 domain containing 2
SPDEF SAM pointed domain containing ETS transcription factor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TM4SF1 transmembrane 4 L six family member 1
TOB1 transducer of ERBB2, 1
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1