BRD-K12393722_1-benzhydryl-4-[(5-methyl-4-nitroisoxazol-3-yl)carbonyl]piperazine BRD-K12393722_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-K12393722_1-benzhydryl-4-[(5-methyl-4-nitroisoxazol-3-yl)carbonyl]piperazine BRD-K12393722_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
C10ORF10 chromosome 10 open reading frame 10
CD163 CD163 molecule
CLEC11A C-type lectin domain family 11, member A
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
RGS1 regulator of G-protein signaling 1
S100A10 S100 calcium binding protein A10
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
IDO1 indoleamine 2,3-dioxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
SDC2 syndecan 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13