BRD-K12343256_trametinib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K12343256_trametinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
CALM3 calmodulin 3 (phosphorylase kinase, delta)
FOS FBJ murine osteosarcoma viral oncogene homolog
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HOXD1 homeobox D1
ISG15 ISG15 ubiquitin-like modifier
LINC00341 long intergenic non-protein coding RNA 341
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
NBEA neurobeachin
PAN2 PAN2 poly(A) specific ribonuclease subunit
SCPEP1 serine carboxypeptidase 1
SLC35E2B solute carrier family 35, member E2B
SOCS2 suppressor of cytokine signaling 2
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGTR1 angiotensin II receptor, type 1
BHLHE40 basic helix-loop-helix family, member e40
C7 complement component 7
CCND1 cyclin D1
CHRDL1 chordin-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F13A1 coagulation factor XIII, A1 polypeptide
FAS Fas cell surface death receptor
GPX3 glutathione peroxidase 3
HOPX HOP homeobox
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB5 integrin, beta 5
LAMP5 lysosomal-associated membrane protein family, member 5
LMNB1 lamin B1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NNMT nicotinamide N-methyltransferase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKP phosphofructokinase, platelet
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PYGL phosphorylase, glycogen, liver
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
SCCPDH saccharopine dehydrogenase (putative)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIAM1 T-cell lymphoma invasion and metastasis 1
TNC tenascin C
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1