BRD-K12343256_trametinib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K12343256_trametinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAA1 acetyl-CoA acyltransferase 1
ACSF2 acyl-CoA synthetase family member 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAD aminolevulinate dehydratase
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APOC3 apolipoprotein C-III
APOM apolipoprotein M
ARMCX2 armadillo repeat containing, X-linked 2
BHMT betaine--homocysteine S-methyltransferase
C1ORF115 chromosome 1 open reading frame 115
C5 complement component 5
CAT catalase
CDO1 cysteine dioxygenase type 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CFB complement factor B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FAM63A family with sequence similarity 63, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HDAC6 histone deacetylase 6
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HP haptoglobin
HSDL2 hydroxysteroid dehydrogenase like 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KLHDC2 kelch domain containing 2
KNG1 kininogen 1
LGALS2 lectin, galactoside-binding, soluble, 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPD1 LY6/PLAUR domain containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
NPC2 Niemann-Pick disease, type C2
PAH phenylalanine hydroxylase
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PFKL phosphofructokinase, liver
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIPOX pipecolic acid oxidase
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCA protein kinase C, alpha
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
RXRA retinoid X receptor, alpha
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TBX2 T-box 2
TMEM97 transmembrane protein 97
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
TST thiosulfate sulfurtransferase (rhodanese)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CCDC86 coiled-coil domain containing 86
CD200 CD200 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL10A1 collagen, type X, alpha 1
CTGF connective tissue growth factor
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DPH2 DPH2 homolog (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM3C family with sequence similarity 3, member C
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT18 keratin 18, type I
L1CAM L1 cell adhesion molecule
LIF leukemia inhibitory factor
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NT5DC2 5'-nucleotidase domain containing 2
PDAP1 PDGFA associated protein 1
PDLIM3 PDZ and LIM domain 3
PELO pelota homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
POU2AF1 POU class 2 associating factor 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TSPAN5 tetraspanin 5
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
VCAN versican
YBX3 Y box binding protein 3