BRD-K12343256_trametinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K12343256_trametinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD9 CD9 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CLU clusterin
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FGFR3 fibroblast growth factor receptor 3
GOLT1B golgi transport 1B
GPC1 glypican 1
GRAMD3 GRAM domain containing 3
GREM1 gremlin 1, DAN family BMP antagonist
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOMER2 homer scaffolding protein 2
HOXD1 homeobox D1
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ITM2C integral membrane protein 2C
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MLF1 myeloid leukemia factor 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
BID BH3 interacting domain death agonist
CCND1 cyclin D1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
ELOVL6 ELOVL fatty acid elongase 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
LDB2 LIM domain binding 2
LRRC17 leucine rich repeat containing 17
MAPK13 mitogen-activated protein kinase 13
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCML1 sex comb on midleg-like 1 (Drosophila)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SMAGP small cell adhesion glycoprotein
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
ZNF83 zinc finger protein 83