BRD-K12343256_trametinib_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K12343256_trametinib_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALB albumin
APOC1 apolipoprotein C-I
AQP1 aquaporin 1 (Colton blood group)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLUL glutamate-ammonia ligase
INSR insulin receptor
MAPT microtubule-associated protein tau
MPO myeloperoxidase
MXRA5 matrix-remodelling associated 5
NUPR1 nuclear protein, transcriptional regulator, 1
PCDH17 protocadherin 17
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPL periplakin
PRTN3 proteinase 3
RAP1GAP RAP1 GTPase activating protein
RIMS3 regulating synaptic membrane exocytosis 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
STC2 stanniocalcin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMOD1 tropomodulin 1
VSNL1 visinin-like 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ANXA5 annexin A5
ARHGAP29 Rho GTPase activating protein 29
ATG3 autophagy related 3
AXL AXL receptor tyrosine kinase
CNN3 calponin 3, acidic
CRISP3 cysteine-rich secretory protein 3
CTSZ cathepsin Z
CXCL5 chemokine (C-X-C motif) ligand 5
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD2 EF-hand domain family, member D2
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
HSPA8 heat shock 70kDa protein 8
ITGB5 integrin, beta 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
NPTX2 neuronal pentraxin II
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
SDC2 syndecan 2
SRGN serglycin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TM4SF1 transmembrane 4 L six family member 1
TSPAN4 tetraspanin 4
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon