BRD-K12343256_trametinib_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

37 genes differentially expressed following the BRD-K12343256_trametinib_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CREB1 cAMP responsive element binding protein 1
EFNB2 ephrin-B2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
C7 complement component 7
CD200 CD200 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGB chromogranin B
DCLK1 doublecortin-like kinase 1
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
STMN2 stathmin 2
THBS2 thrombospondin 2