BRD-K12184916_NVP-BEZ235_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARHGAP32 Rho GTPase activating protein 32
BACE2 beta-site APP-cleaving enzyme 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN3 calpain 3, (p94)
CBR3 carbonyl reductase 3
CD44 CD44 molecule (Indian blood group)
CDK7 cyclin-dependent kinase 7
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CIRBP cold inducible RNA binding protein
CST1 cystatin SN
CTSL cathepsin L
CTSS cathepsin S
DAPK1 death-associated protein kinase 1
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
FAM134B family with sequence similarity 134, member B
FAM65B family with sequence similarity 65, member B
FNDC3B fibronectin type III domain containing 3B
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
FZD5 frizzled class receptor 5
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HES1 hes family bHLH transcription factor 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA1033 KIAA1033
KRT18 keratin 18, type I
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LTA4H leukotriene A4 hydrolase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MGLL monoglyceride lipase
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYO5A myosin VA (heavy chain 12, myoxin)
N4BP2L2 NEDD4 binding protein 2-like 2
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
OPTN optineurin
PARP4 poly (ADP-ribose) polymerase family, member 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POPDC3 popeye domain containing 3
PRAME preferentially expressed antigen in melanoma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RGS20 regulator of G-protein signaling 20
RND3 Rho family GTPase 3
RPL36 ribosomal protein L36
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SCAMP1 secretory carrier membrane protein 1
SDCBP syndecan binding protein (syntenin)
SECISBP2L SECIS binding protein 2-like
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAD3 SMAD family member 3
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SST somatostatin
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
TCTA T-cell leukemia translocation altered
TGIF1 TGFB-induced factor homeobox 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAF5 TNF receptor-associated factor 5
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
UBXN7 UBX domain protein 7
VAT1 vesicle amine transport 1
YBX3 Y box binding protein 3
ZNF217 zinc finger protein 217
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP1 aquaporin 1 (Colton blood group)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND3 cyclin D3
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CFH complement factor H
CHEK2 checkpoint kinase 2
CHGB chromogranin B
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP2 dual specificity phosphatase 2
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FGG fibrinogen gamma chain
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H2BG histone cluster 1, H2bg
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IRF8 interferon regulatory factor 8
JCHAIN joining chain of multimeric IgA and IgM
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
MEF2C myocyte enhancer factor 2C
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MPZL1 myelin protein zero-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
OLFM1 olfactomedin 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGRMC1 progesterone receptor membrane component 1
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
QDPR quinoid dihydropteridine reductase
RELN reelin
RET ret proto-oncogene
RNASE6 ribonuclease, RNase A family, k6
RPN1 ribophorin I
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
ST7 suppression of tumorigenicity 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TMEM97 transmembrane protein 97
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein