BRD-K12184916_NVP-BEZ235_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRG6 adhesion G protein-coupled receptor G6
ALCAM activated leukocyte cell adhesion molecule
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF3 activating transcription factor 3
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CYTH1 cytohesin 1
FOXN3 forkhead box N3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBP1 HMG-box transcription factor 1
IDS iduronate 2-sulfatase
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LAGE3 L antigen family, member 3
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGLL monoglyceride lipase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PTK2 protein tyrosine kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SOX4 SRY (sex determining region Y)-box 4
SYNE2 spectrin repeat containing, nuclear envelope 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BAG2 BCL2-associated athanogene 2
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL13 chemokine (C-X-C motif) ligand 13
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
KLK10 kallikrein-related peptidase 10
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAT2A methionine adenosyltransferase II, alpha
MMP7 matrix metallopeptidase 7
MYLK myosin light chain kinase
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
RAD51C RAD51 paralog C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPL39L ribosomal protein L39-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SPAG4 sperm associated antigen 4
SPP1 secreted phosphoprotein 1
WFDC2 WAP four-disulfide core domain 2
WT1 Wilms tumor 1