BRD-K12184916_NVP-BEZ235_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD11 abhydrolase domain containing 11
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMDHD2 amidohydrolase domain containing 2
ANGPTL2 angiopoietin-like 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
AXIN1 axin 1
C6ORF48 chromosome 6 open reading frame 48
CALML5 calmodulin-like 5
CAMLG calcium modulating ligand
CCDC93 coiled-coil domain containing 93
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNI cyclin I
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CRBN cereblon
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
DDIT3 DNA-damage-inducible transcript 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF3D eukaryotic translation initiation factor 3, subunit D
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
ETHE1 ethylmalonic encephalopathy 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM134A family with sequence similarity 134, member A
FAM50A family with sequence similarity 50, member A
FOXN3 forkhead box N3
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD1 GATA zinc finger domain containing 1
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GUSB glucuronidase, beta
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JOSD1 Josephin domain containing 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5D lysine (K)-specific demethylase 5D
KLHDC2 kelch domain containing 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGLL monoglyceride lipase
MUT methylmalonyl CoA mutase
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NMRK1 nicotinamide riboside kinase 1
NONO non-POU domain containing, octamer-binding
NOTCH1 notch 1
NPC1 Niemann-Pick disease, type C1
OSBPL1A oxysterol binding protein-like 1A
PAWR PRKC, apoptosis, WT1, regulator
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLXNA1 plexin A1
PNKP polynucleotide kinase 3'-phosphatase
PPAP2C phosphatidic acid phosphatase type 2C
PTEN phosphatase and tensin homolog
PTPRO protein tyrosine phosphatase, receptor type, O
QARS glutaminyl-tRNA synthetase
RB1CC1 RB1-inducible coiled-coil 1
RPL36 ribosomal protein L36
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
S100P S100 calcium binding protein P
SCCPDH saccharopine dehydrogenase (putative)
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPP1 tripeptidyl peptidase I
UBXN1 UBX domain protein 1
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WDR19 WD repeat domain 19
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
YPEL1 yippee-like 1 (Drosophila)
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARF4 ADP-ribosylation factor 4
BCLAF1 BCL2-associated transcription factor 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD24 CD24 molecule
CD38 CD38 molecule
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHSY1 chondroitin sulfate synthase 1
CLIC4 chloride intracellular channel 4
CLN5 ceroid-lipofuscinosis, neuronal 5
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
CPE carboxypeptidase E
CTSC cathepsin C
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPT dermatopontin
EAF2 ELL associated factor 2
EGF epidermal growth factor
EIF4E eukaryotic translation initiation factor 4E
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM98A family with sequence similarity 98, member A
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAM1 neural cell adhesion molecule 1
NPR3 natriuretic peptide receptor 3
NRCAM neuronal cell adhesion molecule
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PGM3 phosphoglucomutase 3
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTHLH parathyroid hormone-like hormone
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RRBP1 ribosome binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSU1 Ras suppressor protein 1
SCARB1 scavenger receptor class B, member 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOD2 superoxide dismutase 2, mitochondrial
SRPRB signal recognition particle receptor, B subunit
STC1 stanniocalcin 1
SUB1 SUB1 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPYL1 TSPY-like 1
TTC39A tetratricopeptide repeat domain 39A
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase