BRD-K12184916_NVP-BEZ235_BT20_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_BT20_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADRB2 adrenoceptor beta 2, surface
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLDN10 claudin 10
DSP desmoplakin
EGR1 early growth response 1
EGR3 early growth response 3
ELF5 E74-like factor 5 (ets domain transcription factor)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
FXYD3 FXYD domain containing ion transport regulator 3
GAS7 growth arrest-specific 7
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GRAMD1C GRAM domain containing 1C
HCAR3 hydroxycarboxylic acid receptor 3
IFI27 interferon, alpha-inducible protein 27
LY6E lymphocyte antigen 6 complex, locus E
MYBPC1 myosin binding protein C, slow type
MYO6 myosin VI
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
OXTR oxytocin receptor
PCM1 pericentriolar material 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRAME preferentially expressed antigen in melanoma
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SYT1 synaptotagmin I
TGFBR3 transforming growth factor, beta receptor III
TRIM33 tripartite motif containing 33
TUSC3 tumor suppressor candidate 3
UBXN4 UBX domain protein 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BASP1 brain abundant, membrane attached signal protein 1
CAPG capping protein (actin filament), gelsolin-like
CCND2 cyclin D2
CDC25A cell division cycle 25A
COX7B cytochrome c oxidase subunit VIIb
FCGBP Fc fragment of IgG binding protein
JMJD6 jumonji domain containing 6
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MSMO1 methylsterol monooxygenase 1
MSN moesin
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SLIRP SRA stem-loop interacting RNA binding protein
SPP1 secreted phosphoprotein 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)