BRD-K11911061_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K11911061_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ARL4C ADP-ribosylation factor-like 4C
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHGB chromogranin B
CRIP1 cysteine-rich protein 1 (intestinal)
CX3CL1 chemokine (C-X3-C motif) ligand 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP5 dual specificity phosphatase 5
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GPM6B glycoprotein M6B
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
NARFL nuclear prelamin A recognition factor-like
PALLD palladin, cytoskeletal associated protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SST somatostatin
STC1 stanniocalcin 1
STMN2 stathmin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBQLN2 ubiquilin 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VGLL4 vestigial-like family member 4
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADI1 acireductone dioxygenase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AOX1 aldehyde oxidase 1
CCND1 cyclin D1
CFB complement factor B
CFI complement factor I
CPVL carboxypeptidase, vitellogenic-like
CRLF1 cytokine receptor-like factor 1
CTGF connective tissue growth factor
CTSH cathepsin H
DLC1 DLC1 Rho GTPase activating protein
ECI2 enoyl-CoA delta isomerase 2
EHBP1 EH domain binding protein 1
FAM134B family with sequence similarity 134, member B
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPX3 glutathione peroxidase 3
HLF hepatic leukemia factor
HSPA1A heat shock 70kDa protein 1A
IGFBP4 insulin-like growth factor binding protein 4
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO13 importin 13
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOXL2 lysyl oxidase-like 2
MAN2B1 mannosidase, alpha, class 2B, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MYH10 myosin, heavy chain 10, non-muscle
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRDX2 peroxiredoxin 2
PROS1 protein S (alpha)
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RHOBTB3 Rho-related BTB domain containing 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TMEM123 transmembrane protein 123
TPM1 tropomyosin 1 (alpha)