BRD-K11634954_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K11634954_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
CASP10 caspase 10, apoptosis-related cysteine peptidase
CFB complement factor B
CHMP4A charged multivesicular body protein 4A
CRISP3 cysteine-rich secretory protein 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
FGG fibrinogen gamma chain
HBB hemoglobin, beta
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IRF4 interferon regulatory factor 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LY75 lymphocyte antigen 75
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
NEFH neurofilament, heavy polypeptide
PLA1A phospholipase A1 member A
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SQLE squalene epoxidase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BSG basigin (Ok blood group)
C6ORF62 chromosome 6 open reading frame 62
CD44 CD44 molecule (Indian blood group)
CLPTM1 cleft lip and palate associated transmembrane protein 1
CTSC cathepsin C
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GEM GTP binding protein overexpressed in skeletal muscle
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KLF6 Kruppel-like factor 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
NFIB nuclear factor I/B
PHLDA1 pleckstrin homology-like domain, family A, member 1
SDC4 syndecan 4
SHB Src homology 2 domain containing adaptor protein B
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SRSF5 serine/arginine-rich splicing factor 5
TAGLN2 transgelin 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
VAMP3 vesicle-associated membrane protein 3
WWTR1 WW domain containing transcription regulator 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFAND5 zinc finger, AN1-type domain 5
ZNF586 zinc finger protein 586