BRD-K10916986_S1527_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K10916986_S1527_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BCL7B B-cell CLL/lymphoma 7B
C14ORF1 chromosome 14 open reading frame 1
CALU calumenin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
COL1A1 collagen, type I, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CTSL cathepsin L
CUTA cutA divalent cation tolerance homolog (E. coli)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP3 dual specificity phosphatase 3
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FZD7 frizzled class receptor 7
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP12 matrix metallopeptidase 12
MMP19 matrix metallopeptidase 19
MSMO1 methylsterol monooxygenase 1
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
OLFML2B olfactomedin-like 2B
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNMA2 paraneoplastic Ma antigen 2
PSPH phosphoserine phosphatase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
REG1A regenerating islet-derived 1 alpha
RFC2 replication factor C (activator 1) 2, 40kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGCE sarcoglycan, epsilon
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SQLE squalene epoxidase
TBL2 transducin (beta)-like 2
TLR4 toll-like receptor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TREM1 triggering receptor expressed on myeloid cells 1
UPP1 uridine phosphorylase 1
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
ARHGAP29 Rho GTPase activating protein 29
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAV1 caveolin 1, caveolae protein, 22kDa
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DNTT DNA nucleotidylexotransferase
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB2 erb-b2 receptor tyrosine kinase 2
FGFR3 fibroblast growth factor receptor 3
HES1 hes family bHLH transcription factor 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGLV3-19 immunoglobulin lambda variable 3-19
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
MACF1 microtubule-actin crosslinking factor 1
MEF2C myocyte enhancer factor 2C
MT1E metallothionein 1E
ORM1 orosomucoid 1
PCCB propionyl CoA carboxylase, beta polypeptide
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PRSS23 protease, serine, 23
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMSB15A thymosin beta 15a
TSPAN7 tetraspanin 7
WWTR1 WW domain containing transcription regulator 1