BRD-K10882151_BO2 (inhibits RAD51)_VCAP_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_VCAP_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ANPEP alanyl (membrane) aminopeptidase
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAG3 BCL2-associated athanogene 3
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CBS cystathionine-beta-synthase
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FTH1 ferritin, heavy polypeptide 1
GSE1 Gse1 coiled-coil protein
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTBP3 latent transforming growth factor beta binding protein 3
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MFSD10 major facilitator superfamily domain containing 10
MICALL2 MICAL-like 2
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
NBL1 neuroblastoma 1, DAN family BMP antagonist
NPR3 natriuretic peptide receptor 3
NRIP1 nuclear receptor interacting protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLIN2 perilipin 2
RALGDS ral guanine nucleotide dissociation stimulator
RHOC ras homolog family member C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARF4 ADP-ribosylation factor 4
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CD24 CD24 molecule
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
KIAA0907 KIAA0907
KIAA1598
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LDHB lactate dehydrogenase B
LRRC17 leucine rich repeat containing 17
LUM lumican
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
NAV3 neuron navigator 3
NDN necdin, melanoma antigen (MAGE) family member
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
PALMD palmdelphin
PODXL podocalyxin-like
PPAP2A phosphatidic acid phosphatase type 2A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB38 RAB38, member RAS oncogene family
RPL31 ribosomal protein L31
SCGB2A1 secretoglobin, family 2A, member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
UBE2C ubiquitin-conjugating enzyme E2C
VSNL1 visinin-like 1
ZW10 zw10 kinetochore protein