BRD-K10882151_BO2 (inhibits RAD51)_SW948_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_SW948_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AIM2 absent in melanoma 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CALML3 calmodulin-like 3
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN10 claudin 10
COL6A2 collagen, type VI, alpha 2
CTBP2 C-terminal binding protein 2
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MB myoglobin
MBOAT7 membrane bound O-acyltransferase domain containing 7
MLPH melanophilin
MMP2 matrix metallopeptidase 2
NBPF10 neuroblastoma breakpoint family, member 10
NMRK1 nicotinamide riboside kinase 1
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RTN2 reticulon 2
RYBP RING1 and YY1 binding protein
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
STC1 stanniocalcin 1
TGFA transforming growth factor, alpha
TMEM97 transmembrane protein 97
TSPAN1 tetraspanin 1
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
IFITM3 interferon induced transmembrane protein 3
IQGAP2 IQ motif containing GTPase activating protein 2
LAMP1 lysosomal-associated membrane protein 1
LDHB lactate dehydrogenase B
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MPO myeloperoxidase
MREG melanoregulin
MYO6 myosin VI
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAGL1 pleiomorphic adenoma gene-like 1
PRDX2 peroxiredoxin 2
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
TCF4 transcription factor 4
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VSNL1 visinin-like 1
XK X-linked Kx blood group
ZFP36L2 ZFP36 ring finger protein-like 2