BRD-K10882151_BO2 (inhibits RAD51)_SNUC4_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_SNUC4_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP1 aquaporin 1 (Colton blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
CLTC clathrin, heavy chain (Hc)
CPE carboxypeptidase E
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
GRB10 growth factor receptor-bound protein 10
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KIF14 kinesin family member 14
KLK6 kallikrein-related peptidase 6
KRT17 keratin 17, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LMO4 LIM domain only 4
MAMLD1 mastermind-like domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MCFD2 multiple coagulation factor deficiency 2
MUC16 mucin 16, cell surface associated
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKP2 plakophilin 2
PLXNB2 plexin B2
POSTN periostin, osteoblast specific factor
PTBP2 polypyrimidine tract binding protein 2
PXMP2 peroxisomal membrane protein 2, 22kDa
SFN stratifin
SORBS3 sorbin and SH3 domain containing 3
SPATS2L spermatogenesis associated, serine-rich 2-like
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
CA11 carbonic anhydrase XI
CA12 carbonic anhydrase XII
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CENPE centromere protein E, 312kDa
COLEC12 collectin sub-family member 12
CST7 cystatin F (leukocystatin)
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
DEFA5 defensin, alpha 5, Paneth cell-specific
DLD dihydrolipoamide dehydrogenase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUOX2 dual oxidase 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JCHAIN joining chain of multimeric IgA and IgM
LOX lysyl oxidase
LUM lumican
MFAP4 microfibrillar-associated protein 4
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDN necdin, melanoma antigen (MAGE) family member
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
NRN1 neuritin 1
OLFM4 olfactomedin 4
PF4 platelet factor 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLCB4 phospholipase C, beta 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM34 RNA binding motif protein 34
REG1A regenerating islet-derived 1 alpha
S100A14 S100 calcium binding protein A14
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TMEM123 transmembrane protein 123
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2