BRD-K10882151_BO2 (inhibits RAD51)_SKMEL28_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_SKMEL28_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX15B arachidonate 15-lipoxygenase, type B
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BMP4 bone morphogenetic protein 4
CA4 carbonic anhydrase IV
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FRZB frizzled-related protein
FSD1 fibronectin type III and SPRY domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFT57 intraflagellar transport 57
IL13RA2 interleukin 13 receptor, alpha 2
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
ITM2C integral membrane protein 2C
JAG1 jagged 1
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
MEOX2 mesenchyme homeobox 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSLN mesothelin
MT1F metallothionein 1F
NEFH neurofilament, heavy polypeptide
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
P3H2 prolyl 3-hydroxylase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCI protein kinase C, iota
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SDC4 syndecan 4
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD1 SMAD family member 1
SPARCL1 SPARC-like 1 (hevin)
TBC1D31 TBC1 domain family, member 31
TFPI2 tissue factor pathway inhibitor 2
TRIB3 tribbles pseudokinase 3
TYRP1 tyrosinase-related protein 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCLAF1 BCL2-associated transcription factor 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CAPN3 calpain 3, (p94)
CCNA2 cyclin A2
CD24 CD24 molecule
CDC14B cell division cycle 14B
CFLAR CASP8 and FADD-like apoptosis regulator
CRISP3 cysteine-rich secretory protein 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM111A family with sequence similarity 111, member A
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HOOK2 hook microtubule-tethering protein 2
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LRMP lymphoid-restricted membrane protein
LTF lactotransferrin
LYST lysosomal trafficking regulator
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MEGF9 multiple EGF-like-domains 9
MMD monocyte to macrophage differentiation-associated
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MYO6 myosin VI
NCALD neurocalcin delta
NFIB nuclear factor I/B
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX6 sorting nexin 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TMEM47 transmembrane protein 47
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOX3 TOX high mobility group box family member 3
UPK1B uroplakin 1B
USP6NL USP6 N-terminal like
VAV3 vav 3 guanine nucleotide exchange factor
ZW10 zw10 kinetochore protein