BRD-K10882151_BO2 (inhibits RAD51)_PL21_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_PL21_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ADGRG2 adhesion G protein-coupled receptor G2
AMDHD2 amidohydrolase domain containing 2
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP9A ATPase, class II, type 9A
BAG3 BCL2-associated athanogene 3
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCNI cyclin I
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHMP6 charged multivesicular body protein 6
CLEC2B C-type lectin domain family 2, member B
CNPY3 canopy FGF signaling regulator 3
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPP4 dipeptidyl-peptidase 4
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
EVI2A ecotropic viral integration site 2A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FMO1 flavin containing monooxygenase 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1R insulin-like growth factor 1 receptor
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR6 lysophosphatidic acid receptor 6
LYPD1 LY6/PLAUR domain containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MDK midkine (neurite growth-promoting factor 2)
MGAM maltase-glucoamylase
MME membrane metallo-endopeptidase
MORC4 MORC family CW-type zinc finger 4
MYLK myosin light chain kinase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PTPRO protein tyrosine phosphatase, receptor type, O
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGCE sarcoglycan, epsilon
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLIT2 slit homolog 2 (Drosophila)
SNX7 sorting nexin 7
SPATS2L spermatogenesis associated, serine-rich 2-like
SRGN serglycin
TBC1D31 TBC1 domain family, member 31
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
WSB1 WD repeat and SOCS box containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADRB2 adrenoceptor beta 2, surface
APLP2 amyloid beta (A4) precursor-like protein 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CCND2 cyclin D2
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CHEK1 checkpoint kinase 1
CLIC4 chloride intracellular channel 4
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CXADR coxsackie virus and adenovirus receptor
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HDAC9 histone deacetylase 9
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ICMT isoprenylcysteine carboxyl methyltransferase
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KANK1 KN motif and ankyrin repeat domains 1
KLF4 Kruppel-like factor 4 (gut)
LOC100505650 uncharacterized LOC100505650
LTBP1 latent transforming growth factor beta binding protein 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MTSS1 metastasis suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFIB nuclear factor I/B
NT5DC2 5'-nucleotidase domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
PLCB4 phospholipase C, beta 4
PLTP phospholipid transfer protein
PRDX1 peroxiredoxin 1
PSD3 pleckstrin and Sec7 domain containing 3
RPL10 ribosomal protein L10
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTBN1 spectrin, beta, non-erythrocytic 1
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN13 tetraspanin 13
UBA1 ubiquitin-like modifier activating enzyme 1
WFDC2 WAP four-disulfide core domain 2
XK X-linked Kx blood group