BRD-K10882151_BO2 (inhibits RAD51)_LOVO_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_LOVO_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAX BCL2-associated X protein
CBR1 carbonyl reductase 1
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CFB complement factor B
CHMP4A charged multivesicular body protein 4A
CNOT4 CCR4-NOT transcription complex, subunit 4
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERO1L ERO1-like (S. cerevisiae)
FHL2 four and a half LIM domains 2
GCLM glutamate-cysteine ligase, modifier subunit
GMFB glia maturation factor, beta
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM2 intercellular adhesion molecule 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGKC immunoglobulin kappa constant
ISLR immunoglobulin superfamily containing leucine-rich repeat
LINC00341 long intergenic non-protein coding RNA 341
LTBP2 latent transforming growth factor beta binding protein 2
LTF lactotransferrin
MAPT microtubule-associated protein tau
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDRG1 N-myc downstream regulated 1
NEB nebulin
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PENK proenkephalin
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNM synemin, intermediate filament protein
TAGLN transgelin
TCTN1 tectonic family member 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TMEM100 transmembrane protein 100
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
CAST calpastatin
CCND2 cyclin D2
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLU clusterin
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DUOX2 dual oxidase 2
EBP emopamil binding protein (sterol isomerase)
EREG epiregulin
FAM13A family with sequence similarity 13, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FLRT2 fibronectin leucine rich transmembrane protein 2
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GRAMD3 GRAM domain containing 3
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KRT1 keratin 1, type II
KRT10 keratin 10, type I
LOX lysyl oxidase
LPAR6 lysophosphatidic acid receptor 6
MID1 midline 1
MITF microphthalmia-associated transcription factor
MYOF myoferlin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMU neuromedin U
NPTX2 neuronal pentraxin II
NRGN neurogranin (protein kinase C substrate, RC3)
NXN nucleoredoxin
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PTTG1 pituitary tumor-transforming 1
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX11 SRY (sex determining region Y)-box 11
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2A tubulin, beta 2A class IIa
TYRP1 tyrosinase-related protein 1