BRD-K10882151_BO2 (inhibits RAD51)_HT29_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

294 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_HT29_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BMP7 bone morphogenetic protein 7
BRD4 bromodomain containing 4
CALCOCO2 calcium binding and coiled-coil domain 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST1 cystatin SN
CSTB cystatin B (stefin B)
CTH cystathionine gamma-lyase
CTSB cathepsin B
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EMC3 ER membrane protein complex subunit 3
EMP3 epithelial membrane protein 3
EPHA2 EPH receptor A2
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDI1 GDP dissociation inhibitor 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLIPR1 GLI pathogenesis-related 1
GPC1 glypican 1
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT6A keratin 6A, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LMO4 LIM domain only 4
LOXL2 lysyl oxidase-like 2
LYPD3 LY6/PLAUR domain containing 3
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MED13 mediator complex subunit 13
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NBPF10 neuroblastoma breakpoint family, member 10
NEFL neurofilament, light polypeptide
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
ODC1 ornithine decarboxylase 1
OLFML2B olfactomedin-like 2B
OSMR oncostatin M receptor
OSTM1 osteopetrosis associated transmembrane protein 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PRDX1 peroxiredoxin 1
PROCR protein C receptor, endothelial
PTGES prostaglandin E synthase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS20 regulator of G-protein signaling 20
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SLC16A6 solute carrier family 16, member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC38A6 solute carrier family 38, member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMOX spermine oxidase
SPATS2L spermatogenesis associated, serine-rich 2-like
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STAB1 stabilin 1
STATH statherin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STXBP1 syntaxin binding protein 1
TDO2 tryptophan 2,3-dioxygenase
TFE3 transcription factor binding to IGHM enhancer 3
TGFA transforming growth factor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNPO1 transportin 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WBP2 WW domain binding protein 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AHCY adenosylhomocysteinase
AHR aryl hydrocarbon receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANOS1 anosmin 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID5B AT rich interactive domain 5B (MRF1-like)
ASRGL1 asparaginase like 1
B3GNT1
C7 complement component 7
CCND2 cyclin D2
CCNE2 cyclin E2
CCNG1 cyclin G1
CD200 CD200 molecule
CD24 CD24 molecule
CD320 CD320 molecule
CDK1 cyclin-dependent kinase 1
CFI complement factor I
CLC Charcot-Leyden crystal galectin
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRIP1 cysteine-rich protein 1 (intestinal)
CS citrate synthase
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN1 endothelin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FABP1 fatty acid binding protein 1, liver
FAM13A family with sequence similarity 13, member A
FAR2 fatty acyl CoA reductase 2
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GZMK granzyme K (granzyme 3; tryptase II)
H1FX H1 histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HLF hepatic leukemia factor
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IVNS1ABP influenza virus NS1A binding protein
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KLHL9 kelch-like family member 9
LAMB1 laminin, beta 1
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
LUM lumican
LY75 lymphocyte antigen 75
LYZ lysozyme
MCM2 minichromosome maintenance complex component 2
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MSH6 mutS homolog 6
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
MYO5C myosin VC
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALMD palmdelphin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCCB propionyl CoA carboxylase, beta polypeptide
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDZRN3 PDZ domain containing ring finger 3
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLN phospholamban
PPA2 pyrophosphatase (inorganic) 2
PRDX2 peroxiredoxin 2
PRR15L proline rich 15-like
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RELN reelin
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS11 ribosomal protein S11
SALL2 spalt-like transcription factor 2
SCGB2A1 secretoglobin, family 2A, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THYN1 thymocyte nuclear protein 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPO thymopoietin
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
ZFPM2 zinc finger protein, FOG family member 2