BRD-K10882151_BO2 (inhibits RAD51)_HT115_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_HT115_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BIN1 bridging integrator 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CLU clusterin
CREM cAMP responsive element modulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EREG epiregulin
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IDE insulin-degrading enzyme
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IGFBP4 insulin-like growth factor binding protein 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
MBP myelin basic protein
MMD monocyte to macrophage differentiation-associated
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PDGFRL platelet-derived growth factor receptor-like
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PRNP prion protein
RBP4 retinol binding protein 4, plasma
REG3A regenerating islet-derived 3 alpha
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SRPX sushi-repeat containing protein, X-linked
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TM4SF4 transmembrane 4 L six family member 4
TRIM16 tripartite motif containing 16
TSPO translocator protein (18kDa)
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ANOS1 anosmin 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
C1ORF116 chromosome 1 open reading frame 116
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLEC7A C-type lectin domain family 7, member A
CXCL13 chemokine (C-X-C motif) ligand 13
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
EIF5 eukaryotic translation initiation factor 5
FAR2 fatty acyl CoA reductase 2
FOLR1 folate receptor 1 (adult)
HOPX HOP homeobox
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
NARFL nuclear prelamin A recognition factor-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPTX2 neuronal pentraxin II
NSG1 neuron specific gene family member 1
OXA1L oxidase (cytochrome c) assembly 1-like
PDGFC platelet derived growth factor C
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POSTN periostin, osteoblast specific factor
PRKCB protein kinase C, beta
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFTPD surfactant protein D
SHB Src homology 2 domain containing adaptor protein B
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOSTDC1 sclerostin domain containing 1
SPEN spen family transcriptional repressor
SULF1 sulfatase 1
TCF4 transcription factor 4
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSPAN13 tetraspanin 13