BRD-K10882151_BO2 (inhibits RAD51)_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CECR1 cat eye syndrome chromosome region, candidate 1
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FDPS farnesyl diphosphate synthase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLK6 kallikrein-related peptidase 6
LDLR low density lipoprotein receptor
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
MSMO1 methylsterol monooxygenase 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPTX2 neuronal pentraxin II
PEG3 paternally expressed 3
PLEC plectin
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
STAR steroidogenic acute regulatory protein
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADAM19 ADAM metallopeptidase domain 19
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMACR alpha-methylacyl-CoA racemase
APMAP adipocyte plasma membrane associated protein
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BCHE butyrylcholinesterase
CCDC86 coiled-coil domain containing 86
CCNA1 cyclin A1
CERS6 ceramide synthase 6
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL9A3 collagen, type IX, alpha 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP7 fatty acid binding protein 7, brain
FASTKD5 FAST kinase domains 5
FERMT2 fermitin family member 2
FMO3 flavin containing monooxygenase 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIAA0485 uncharacterized LOC57235
LAMB1 laminin, beta 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MRPL19 mitochondrial ribosomal protein L19
OLFM4 olfactomedin 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEBP1 phosphatidylethanolamine binding protein 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TCF4 transcription factor 4
TFRC transferrin receptor
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28