BRD-K10882151_BO2 (inhibits RAD51)_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ALAS1 5'-aminolevulinate synthase 1
ANPEP alanyl (membrane) aminopeptidase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BPIFA1 BPI fold containing family A, member 1
BPTF bromodomain PHD finger transcription factor
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CCND3 cyclin D3
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSB cathepsin B
CTSL cathepsin L
CYBA cytochrome b-245, alpha polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DMBT1 deleted in malignant brain tumors 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
ETV1 ets variant 1
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GALE UDP-galactose-4-epimerase
GDF15 growth differentiation factor 15
GLG1 golgi glycoprotein 1
GSTZ1 glutathione S-transferase zeta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INHBE inhibin, beta E
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LPAR2 lysophosphatidic acid receptor 2
MBD4 methyl-CpG binding domain protein 4
MED1 mediator complex subunit 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLD3 phospholipase D family, member 3
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRRC2C proline-rich coiled-coil 2C
PTP4A1 protein tyrosine phosphatase type IVA, member 1
SCG5 secretogranin V
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
TGOLN2 trans-golgi network protein 2
TMEM5 transmembrane protein 5
TPP1 tripeptidyl peptidase I
TPR translocated promoter region, nuclear basket protein
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
WIF1 WNT inhibitory factor 1
WNK1 WNK lysine deficient protein kinase 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZNF638 zinc finger protein 638
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTC1 actin, alpha, cardiac muscle 1
ACTN4 actinin, alpha 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATXN1 ataxin 1
AUTS2 autism susceptibility candidate 2
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CALD1 caldesmon 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDA cytidine deaminase
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC5 chloride intracellular channel 5
CNN1 calponin 1, basic, smooth muscle
CNN3 calponin 3, acidic
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYC1 cytochrome c-1
CYTH1 cytohesin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND5A DENN/MADD domain containing 5A
DLD dihydrolipoamide dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FAM171A1 family with sequence similarity 171, member A1
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
FLNB filamin B, beta
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP4 GTP binding protein 4
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MBNL1 muscleblind-like splicing regulator 1
MECOM MDS1 and EVI1 complex locus
MGP matrix Gla protein
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMT2 N-myristoyltransferase 2
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NXN nucleoredoxin
OLFM4 olfactomedin 4
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PDLIM1 PDZ and LIM domain 1
PDLIM3 PDZ and LIM domain 3
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RPL37A ribosomal protein L37a
RSU1 Ras suppressor protein 1
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SEC23A Sec23 homolog A (S. cerevisiae)
SELE selectin E
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD7 SMAD family member 7
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
SULF1 sulfatase 1
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TLE4 transducin-like enhancer of split 4
TM4SF1 transmembrane 4 L six family member 1
TMEM14B transmembrane protein 14B
TMOD1 tropomodulin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TUFT1 tuftelin 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
WWTR1 WW domain containing transcription regulator 1