BRD-K10882151_BO2 (inhibits RAD51)_DV90_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_DV90_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BAG3 BCL2-associated athanogene 3
C14ORF132 chromosome 14 open reading frame 132
CADM1 cell adhesion molecule 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST1 cystatin SN
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
EFS embryonal Fyn-associated substrate
FADS1 fatty acid desaturase 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
JUN jun proto-oncogene
KRT5 keratin 5, type II
MAP1B microtubule-associated protein 1B
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
NEFH neurofilament, heavy polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
TBX3 T-box 3
TMEM41B transmembrane protein 41B
TPP1 tripeptidyl peptidase I
TXNRD1 thioredoxin reductase 1
VWF von Willebrand factor
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDOB aldolase B, fructose-bisphosphate
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCND1 cyclin D1
CD24 CD24 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCLK1 doublecortin-like kinase 1
DUOX2 dual oxidase 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPRC5A G protein-coupled receptor, class C, group 5, member A
HHEX hematopoietically expressed homeobox
HMG20B high mobility group 20B
HOXC6 homeobox C6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MFSD10 major facilitator superfamily domain containing 10
MRPS2 mitochondrial ribosomal protein S2
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NNT nicotinamide nucleotide transhydrogenase
ORC1 origin recognition complex, subunit 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCSK6 proprotein convertase subtilisin/kexin type 6
PDZK1IP1 PDZK1 interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRR15L proline rich 15-like
PTP4A2 protein tyrosine phosphatase type IVA, member 2
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SUN1 Sad1 and UNC84 domain containing 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
WNT5A wingless-type MMTV integration site family, member 5A