BRD-K10882151_BO2 (inhibits RAD51)_A673_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_A673_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
AQP9 aquaporin 9
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
CD14 CD14 molecule
CLMN calmin (calponin-like, transmembrane)
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
HBEGF heparin-binding EGF-like growth factor
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHMBP2 immunoglobulin mu binding protein 2
INSIG1 insulin induced gene 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LPAR2 lysophosphatidic acid receptor 2
MAGEA12 melanoma antigen family A12
MME membrane metallo-endopeptidase
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIH1D1 PIH1 domain containing 1
PIR pirin (iron-binding nuclear protein)
PRSS3 protease, serine, 3
RAB20 RAB20, member RAS oncogene family
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC35E3 solute carrier family 35, member E3
SLC35F2 solute carrier family 35, member F2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TMEM97 transmembrane protein 97
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ANXA1 annexin A1
AREG amphiregulin
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTBD3 BTB (POZ) domain containing 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNE2 cyclin E2
CD24 CD24 molecule
CLIC4 chloride intracellular channel 4
CRABP1 cellular retinoic acid binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYTIP cytohesin 1 interacting protein
CYTL1 cytokine-like 1
DEPTOR DEP domain containing MTOR-interacting protein
DPH2 DPH2 homolog (S. cerevisiae)
DPYSL3 dihydropyrimidinase-like 3
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FZD7 frizzled class receptor 7
GPC4 glypican 4
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
LPL lipoprotein lipase
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
NNMT nicotinamide N-methyltransferase
NTS neurotensin
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODXL podocalyxin-like
RAB31 RAB31, member RAS oncogene family
SATB2 SATB homeobox 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
STOM stomatin
TGM2 transglutaminase 2
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM22 tripartite motif containing 22
TXNDC9 thioredoxin domain containing 9
VGLL4 vestigial-like family member 4
VSNL1 visinin-like 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZW10 zw10 kinetochore protein