BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX2 acyl-CoA oxidase 2, branched chain
ADM adrenomedullin
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R2 cytochrome b5 reductase 2
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
EZR ezrin
F11R F11 receptor
F12 coagulation factor XII (Hageman factor)
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PRR7 proline rich 7 (synaptic)
PRTN3 proteinase 3
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SGK1 serum/glucocorticoid regulated kinase 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
SULF1 sulfatase 1
TCEAL2 transcription elongation factor A (SII)-like 2
TCF21 transcription factor 21
TEK TEK tyrosine kinase, endothelial
TF transferrin
THBS2 thrombospondin 2
TPBG trophoblast glycoprotein
TXNIP thioredoxin interacting protein
UGP2 UDP-glucose pyrophosphorylase 2
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BASP1 brain abundant, membrane attached signal protein 1
CBR3 carbonyl reductase 3
CBX5 chromobox homolog 5
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CUL2 cullin 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ETV5 ets variant 5
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FOXJ3 forkhead box J3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLM1 golgi membrane protein 1
GRWD1 glutamate-rich WD repeat containing 1
HDAC1 histone deacetylase 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
KAT6A K(lysine) acetyltransferase 6A
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KRT81 keratin 81, type II
LIMA1 LIM domain and actin binding 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MTCL1 microtubule crosslinking factor 1
NCOA6 nuclear receptor coactivator 6
NCOR2 nuclear receptor corepressor 2
NET1 neuroepithelial cell transforming 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PANK2 pantothenate kinase 2
PDLIM5 PDZ and LIM domain 5
PDS5B PDS5 cohesin associated factor B
PLCB4 phospholipase C, beta 4
PPIF peptidylprolyl isomerase F
PPP4R1 protein phosphatase 4, regulatory subunit 1
PRPF4 pre-mRNA processing factor 4
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RBBP4 retinoblastoma binding protein 4
RNMT RNA (guanine-7-) methyltransferase
RPL36 ribosomal protein L36
RPS4Y1 ribosomal protein S4, Y-linked 1
SEH1L SEH1-like (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SPATA20 spermatogenesis associated 20
ST7 suppression of tumorigenicity 7
TARP TCR gamma alternate reading frame protein
TCAF1 TRPM8 channel-associated factor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRAPPC3 trafficking protein particle complex 3
TRIM28 tripartite motif containing 28
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3C ubiquitin protein ligase E3C
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VGLL4 vestigial-like family member 4
ZMYM2 zinc finger, MYM-type 2