BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD17A abhydrolase domain containing 17A
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
C6ORF62 chromosome 6 open reading frame 62
CFB complement factor B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
DCN decorin
DUSP1 dual specificity phosphatase 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
GJA1 gap junction protein, alpha 1, 43kDa
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFT57 intraflagellar transport 57
KRT5 keratin 5, type II
MCUR1 mitochondrial calcium uniporter regulator 1
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
NEFH neurofilament, heavy polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO2 NAD(P)H dehydrogenase, quinone 2
NUCB1 nucleobindin 1
ORM1 orosomucoid 1
SCARB2 scavenger receptor class B, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SPARCL1 SPARC-like 1 (hevin)
TGFB1 transforming growth factor, beta 1
TMEM14B transmembrane protein 14B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AFF1 AF4/FMR2 family, member 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARMCX6 armadillo repeat containing, X-linked 6
AXL AXL receptor tyrosine kinase
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
FBXO11 F-box protein 11
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GLDC glycine dehydrogenase (decarboxylating)
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MID1 midline 1
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
PFKP phosphofructokinase, platelet
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTX3 pentraxin 3, long
RNMT RNA (guanine-7-) methyltransferase
SETD5 SET domain containing 5
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b