BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
CA4 carbonic anhydrase IV
CD36 CD36 molecule (thrombospondin receptor)
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDNRB endothelin receptor type B
EMP1 epithelial membrane protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAS7 growth arrest-specific 7
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT20 keratin 20, type I
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NLGN4X neuroligin 4, X-linked
NMU neuromedin U
NSG1 neuron specific gene family member 1
OLFM4 olfactomedin 4
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
TARP TCR gamma alternate reading frame protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
UGP2 UDP-glucose pyrophosphorylase 2
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VIM vimentin
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FAM102A family with sequence similarity 102, member A
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IPO7 importin 7
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
KYNU kynureninase
LARP4 La ribonucleoprotein domain family, member 4
MED13 mediator complex subunit 13
MPZL2 myelin protein zero-like 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NOP2 NOP2 nucleolar protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
PALLD palladin, cytoskeletal associated protein
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
RAD9A RAD9 homolog A (S. pombe)
SCAF8 SR-related CTD-associated factor 8
SEPHS1 selenophosphate synthetase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
TACC2 transforming, acidic coiled-coil containing protein 2
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM243 transmembrane protein 243, mitochondrial
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMYM2 zinc finger, MYM-type 2