BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP9 aquaporin 9
ASPN asporin
BEX1 brain expressed, X-linked 1
BSG basigin (Ok blood group)
CD24 CD24 molecule
CD99 CD99 molecule
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYR61 cysteine-rich, angiogenic inducer, 61
DBN1 drebrin 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNTT DNA nucleotidylexotransferase
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPM6A glycoprotein M6A
GUSBP3 glucuronidase, beta pseudogene 3
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KIAA0226L KIAA0226-like
L1CAM L1 cell adhesion molecule
LEF1 lymphoid enhancer-binding factor 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBOAT2 membrane bound O-acyltransferase domain containing 2
NLGN4X neuroligin 4, X-linked
NREP neuronal regeneration related protein
PDLIM1 PDZ and LIM domain 1
PGK1 phosphoglycerate kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
S100A7 S100 calcium binding protein A7
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
VIM vimentin

decreased expression

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGO2 argonaute RISC catalytic component 2
ARID4B AT rich interactive domain 4B (RBP1-like)
AURKA aurora kinase A
AXIN1 axin 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
BRIX1 BRX1, biogenesis of ribosomes
C10ORF2 chromosome 10 open reading frame 2
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CAPN6 calpain 6
CCNA2 cyclin A2
CCNF cyclin F
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDK7 cyclin-dependent kinase 7
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CREBBP CREB binding protein
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EED embryonic ectoderm development
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FAM208B family with sequence similarity 208, member B
FBXO11 F-box protein 11
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GGNBP2 gametogenetin binding protein 2
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
HOXA5 homeobox A5
HSPA14 heat shock 70kDa protein 14
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIN Kin17 DNA and RNA binding protein
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LARP4B La ribonucleoprotein domain family, member 4B
LHFPL2 lipoma HMGIC fusion partner-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MGLL monoglyceride lipase
MTF2 metal response element binding transcription factor 2
MTPAP mitochondrial poly(A) polymerase
NCK1 NCK adaptor protein 1
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PXDC1 PX domain containing 1
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAFB2 scaffold attachment factor B2
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SEPHS1 selenophosphate synthetase 1
SESN1 sestrin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SMNDC1 survival motor neuron domain containing 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THAP11 THAP domain containing 11
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TOB2 transducer of ERBB2, 2
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRPS1 trichorhinophalangeal syndrome I
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UMPS uridine monophosphate synthetase
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP22 ubiquitin specific peptidase 22
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2
ZNF22 zinc finger protein 22