BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

255 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AK4 adenylate kinase 4
BSG basigin (Ok blood group)
C3ORF14 chromosome 3 open reading frame 14
C9ORF16 chromosome 9 open reading frame 16
CCNE2 cyclin E2
CD24 CD24 molecule
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ESRP1 epithelial splicing regulatory protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HRSP12 heat-responsive protein 12
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL7R interleukin 7 receptor
JUN jun proto-oncogene
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
LEF1 lymphoid enhancer-binding factor 1
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
MOXD1 monooxygenase, DBH-like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PGK1 phosphoglycerate kinase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SDC2 syndecan 2
SEPT2 septin 2
SERINC3 serine incorporator 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNX10 sorting nexin 10
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG1 TP53 target 1 (non-protein coding)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AMD1 adenosylmethionine decarboxylase 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATMIN ATM interactor
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
BUB3 BUB3 mitotic checkpoint protein
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP2 cytoskeleton associated protein 2
COIL coilin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
FAM208B family with sequence similarity 208, member B
FAM98A family with sequence similarity 98, member A
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FNBP4 formin binding protein 4
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GEMIN4 gem (nuclear organelle) associated protein 4
GGNBP2 gametogenetin binding protein 2
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOPX HOP homeobox
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IQGAP2 IQ motif containing GTPase activating protein 2
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MED17 mediator complex subunit 17
MELK maternal embryonic leucine zipper kinase
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MSH6 mutS homolog 6
MSL2 male-specific lethal 2 homolog (Drosophila)
MTF2 metal response element binding transcription factor 2
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFYA nuclear transcription factor Y, alpha
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP153 nucleoporin 153kDa
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PALB2 partner and localizer of BRCA2
PDS5B PDS5 cohesin associated factor B
PDZD8 PDZ domain containing 8
PHF3 PHD finger protein 3
PHIP pleckstrin homology domain interacting protein
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTRH2 peptidyl-tRNA hydrolase 2
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RBM39 RNA binding motif protein 39
RHOBTB3 Rho-related BTB domain containing 3
RHOF ras homolog family member F (in filopodia)
RNF6 ring finger protein (C3H2C3 type) 6
RPP38 ribonuclease P/MRP 38kDa subunit
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SCAF8 SR-related CTD-associated factor 8
SEC24B SEC24 family member B
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SETD2 SET domain containing 2
SETD5 SET domain containing 5
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
U2SURP U2 snRNP-associated SURP domain containing
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDC1 YTH domain containing 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB1 zinc finger and BTB domain containing 1
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC7 zinc finger, DHHC-type containing 7
ZMYM2 zinc finger, MYM-type 2
ZNF451 zinc finger protein 451