BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

290 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
AEBP1 AE binding protein 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
CD14 CD14 molecule
CD163 CD163 molecule
CD177 CD177 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD48 CD48 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CYBB cytochrome b-245, beta polypeptide
DCN decorin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP1 endoplasmic reticulum aminopeptidase 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPX3 glutathione peroxidase 3
GUK1 guanylate kinase 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KIAA0226L KIAA0226-like
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LPAR6 lysophosphatidic acid receptor 6
LPL lipoprotein lipase
LTB lymphotoxin beta (TNF superfamily, member 3)
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPR3 natriuretic peptide receptor 3
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SSBP2 single-stranded DNA binding protein 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TCL1A T-cell leukemia/lymphoma 1A
THY1 Thy-1 cell surface antigen
TMEM176B transmembrane protein 176B
TMEM230 transmembrane protein 230
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AHNAK AHNAK nucleoprotein
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASF1A anti-silencing function 1A histone chaperone
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCOR BCL6 corepressor
BEX1 brain expressed, X-linked 1
BLMH bleomycin hydrolase
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSRP1 cysteine and glycine-rich protein 1
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEFB1 defensin, beta 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADD Fas (TNFRSF6)-associated via death domain
FAM222B family with sequence similarity 222, member B
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FBXO34 F-box protein 34
FOSL1 FOS-like antigen 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GEMIN4 gem (nuclear organelle) associated protein 4
GLDC glycine dehydrogenase (decarboxylating)
GOSR1 golgi SNAP receptor complex member 1
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFX H2A histone family, member X
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF1BP KIF1 binding protein
KIF2C kinesin family member 2C
KIF5C kinesin family member 5C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MEPCE methylphosphate capping enzyme
MRPS30 mitochondrial ribosomal protein S30
MRPS7 mitochondrial ribosomal protein S7
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOL11 nucleolar protein 11
NOTCH2NL notch 2 N-terminal like
NPAT nuclear protein, ataxia-telangiectasia locus
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRRC2C proline-rich coiled-coil 2C
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
RNF219 ring finger protein 219
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEC24B SEC24 family member B
SECISBP2L SECIS binding protein 2-like
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SPATA5L1 spermatogenesis associated 5-like 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNJ2 synaptojanin 2
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VAV3 vav 3 guanine nucleotide exchange factor
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF189 zinc finger protein 189
ZNF217 zinc finger protein 217
ZNF267 zinc finger protein 267
ZNF281 zinc finger protein 281
ZNF451 zinc finger protein 451