BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
ARG2 arginase 2
BGN biglycan
BLNK B-cell linker
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD177 CD177 molecule
CD47 CD47 molecule
CD9 CD9 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
COLEC12 collectin sub-family member 12
CTSB cathepsin B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FAM198B family with sequence similarity 198, member B
FILIP1L filamin A interacting protein 1-like
FLNA filamin A, alpha
FLOT1 flotillin 1
FLT1 fms-related tyrosine kinase 1
GPC4 glypican 4
GPM6A glycoprotein M6A
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
HPSE heparanase
HSPG2 heparan sulfate proteoglycan 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP6 insulin-like growth factor binding protein 6
KIAA1462 KIAA1462
L1CAM L1 cell adhesion molecule
LAPTM5 lysosomal protein transmembrane 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
LTA4H leukotriene A4 hydrolase
MAOB monoamine oxidase B
MDFIC MyoD family inhibitor domain containing
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
ORM1 orosomucoid 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGS1 regulator of G-protein signaling 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SNX10 sorting nexin 10
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TPM2 tropomyosin 2 (beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WASF1 WAS protein family, member 1
WLS wntless Wnt ligand secretion mediator
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP350 centrosomal protein 350kDa
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CRY1 cryptochrome circadian clock 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
EIF5 eukaryotic translation initiation factor 5
EXOSC4 exosome component 4
FAM102A family with sequence similarity 102, member A
FAM208B family with sequence similarity 208, member B
FBXO11 F-box protein 11
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KIAA0355 KIAA0355
KLF4 Kruppel-like factor 4 (gut)
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MTF2 metal response element binding transcription factor 2
N4BP2L2 NEDD4 binding protein 2-like 2
NCALD neurocalcin delta
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGDN neuroguidin, EIF4E binding protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOP16 NOP16 nucleolar protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
QKI QKI, KH domain containing, RNA binding
RAD9A RAD9 homolog A (S. pombe)
RPP38 ribonuclease P/MRP 38kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNX11 sorting nexin 11
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
ZBTB38 zinc finger and BTB domain containing 38
ZCCHC8 zinc finger, CCHC domain containing 8