BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

303 genes differentially expressed following the BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACAT1 acetyl-CoA acetyltransferase 1
ACLY ATP citrate lyase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CD163 CD163 molecule
CD69 CD69 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CFLAR CASP8 and FADD-like apoptosis regulator
CKB creatine kinase, brain
COL3A1 collagen, type III, alpha 1
CRIP2 cysteine-rich protein 2
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GANAB glucosidase, alpha; neutral AB
GATA2 GATA binding protein 2
GDI2 GDP dissociation inhibitor 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
HDLBP high density lipoprotein binding protein
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP3 latent transforming growth factor beta binding protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDFIC MyoD family inhibitor domain containing
MOXD1 monooxygenase, DBH-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPDC1 neural proliferation, differentiation and control, 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSENEN presenilin enhancer gamma secretase subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPT2 septin 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX4 SRY (sex determining region Y)-box 4
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
TRIB1 tribbles pseudokinase 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
AIM1 absent in melanoma 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASF1A anti-silencing function 1A histone chaperone
ATF1 activating transcription factor 1
AURKA aurora kinase A
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDK8 cyclin-dependent kinase 8
CDKN2AIP CDKN2A interacting protein
CEP350 centrosomal protein 350kDa
CEP76 centrosomal protein 76kDa
CHD1 chromodomain helicase DNA binding protein 1
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
CHSY1 chondroitin sulfate synthase 1
COIL coilin
CRY1 cryptochrome circadian clock 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTSG cathepsin G
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELANE elastase, neutrophil expressed
ELMO1 engulfment and cell motility 1
EXOSC8 exosome component 8
FAM193A family with sequence similarity 193, member A
FAM208B family with sequence similarity 208, member B
FAM222B family with sequence similarity 222, member B
FASTKD5 FAST kinase domains 5
FBXO28 F-box protein 28
FBXO34 F-box protein 34
FNBP1L formin binding protein 1-like
FOXJ3 forkhead box J3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HIC2 hypermethylated in cancer 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IPO7 importin 7
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KLHL9 kelch-like family member 9
KRBOX4 KRAB box domain containing 4
KYNU kynureninase
LIPT1 lipoyltransferase 1
LPL lipoprotein lipase
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MED21 mediator complex subunit 21
METTL13 methyltransferase like 13
MGA MGA, MAX dimerization protein
MGLL monoglyceride lipase
MID1 midline 1
MIS12 MIS12 kinetochore complex component
MRFAP1L1 Morf4 family associated protein 1-like 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTERF3 mitochondrial transcription termination factor 3
MTF2 metal response element binding transcription factor 2
MTPAP mitochondrial poly(A) polymerase
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP153 nucleoporin 153kDa
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PALB2 partner and localizer of BRCA2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDS5B PDS5 cohesin associated factor B
PLAC8 placenta-specific 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PRRC2C proline-rich coiled-coil 2C
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PTRH2 peptidyl-tRNA hydrolase 2
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFC3 replication factor C (activator 1) 3, 38kDa
RIN2 Ras and Rab interactor 2
RMI1 RecQ mediated genome instability 1
RNF111 ring finger protein 111
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF219 ring finger protein 219
RNF4 ring finger protein 4
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RREB1 ras responsive element binding protein 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSBN1 round spermatid basic protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRPG small nuclear ribonucleoprotein polypeptide G
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TEX10 testis expressed 10
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM11 transmembrane protein 11
TMEM30B transmembrane protein 30B
TRAPPC3 trafficking protein particle complex 3
TRIM29 tripartite motif containing 29
TRIM32 tripartite motif containing 32
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
WAPAL wings apart-like homolog (Drosophila)
WDR3 WD repeat domain 3
WEE1 WEE1 G2 checkpoint kinase
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBED5 zinc finger, BED-type containing 5
ZBTB1 zinc finger and BTB domain containing 1
ZBTB11 zinc finger and BTB domain containing 11
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF189 zinc finger protein 189
ZNF22 zinc finger protein 22
ZNF232 zinc finger protein 232
ZNF263 zinc finger protein 263
ZNF84 zinc finger protein 84
ZZZ3 zinc finger, ZZ-type containing 3