BRD-K10705233_GW405833 hydrochloride_THP1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_THP1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C3ORF14 chromosome 3 open reading frame 14
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLEC3B C-type lectin domain family 3, member B
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CTBP2 C-terminal binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
LGALS1 lectin, galactoside-binding, soluble, 1
LITAF lipopolysaccharide-induced TNF factor
LPAR6 lysophosphatidic acid receptor 6
MAGED2 melanoma antigen family D2
MAP3K7CL MAP3K7 C-terminal like
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MSMB microseminoprotein, beta-
MX1 MX dynamin-like GTPase 1
NEB nebulin
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCL1 phospholipase C-like 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSAD2 radical S-adenosyl methionine domain containing 2
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TACC2 transforming, acidic coiled-coil containing protein 2
TBX3 T-box 3
TES testin LIM domain protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANKRD10 ankyrin repeat domain 10
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
C1S complement component 1, s subcomponent
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC11A C-type lectin domain family 11, member A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSG cathepsin G
CXCR4 chemokine (C-X-C motif) receptor 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEFB1 defensin, beta 1
DPH2 DPH2 homolog (S. cerevisiae)
ESR1 estrogen receptor 1
FAM216A family with sequence similarity 216, member A
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
ICMT isoprenylcysteine carboxyl methyltransferase
JMJD6 jumonji domain containing 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
LYST lysosomal trafficking regulator
MCM4 minichromosome maintenance complex component 4
MRPS2 mitochondrial ribosomal protein S2
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
PA2G4 proliferation-associated 2G4, 38kDa
PKM pyruvate kinase, muscle
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
RPL17 ribosomal protein L17
RRP1B ribosomal RNA processing 1B
S100A9 S100 calcium binding protein A9
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
TATDN2 TatD DNase domain containing 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TPM4 tropomyosin 4
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN3 tetraspanin 3
UBE2G2 ubiquitin-conjugating enzyme E2G 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon