BRD-K10705233_GW405833 hydrochloride_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
BHLHE41 basic helix-loop-helix family, member e41
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPA3 carboxypeptidase A3 (mast cell)
CTGF connective tissue growth factor
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EZR ezrin
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IGFBP6 insulin-like growth factor binding protein 6
INHBE inhibin, beta E
IRF6 interferon regulatory factor 6
ISG20 interferon stimulated exonuclease gene 20kDa
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSAT1 phosphoserine aminotransferase 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RND3 Rho family GTPase 3
SFN stratifin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TXNIP thioredoxin interacting protein
XPOT exportin, tRNA

decreased expression

Symbol Name
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
AFP alpha-fetoprotein
ALB albumin
ANKRD46 ankyrin repeat domain 46
BIRC5 baculoviral IAP repeat containing 5
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCL4 chemokine (C-C motif) ligand 4
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES1 carboxylesterase 1
CKB creatine kinase, brain
CTPS1 CTP synthase 1
CTSH cathepsin H
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JAG1 jagged 1
MEIS2 Meis homeobox 2
MSLN mesothelin
PCP4 Purkinje cell protein 4
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
RAP2C RAP2C, member of RAS oncogene family
RPIA ribose 5-phosphate isomerase A
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
UBE3C ubiquitin protein ligase E3C
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WT1 Wilms tumor 1