BRD-K10705233_GW405833 hydrochloride_SKMEL28_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_SKMEL28_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ANKRD11 ankyrin repeat domain 11
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CLIC4 chloride intracellular channel 4
COL9A3 collagen, type IX, alpha 3
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EREG epiregulin
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IL6 interleukin 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LYZ lysozyme
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MGP matrix Gla protein
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PALLD palladin, cytoskeletal associated protein
PFN2 profilin 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB2A RAB2A, member RAS oncogene family
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TAC1 tachykinin, precursor 1
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL2 adhesion G protein-coupled receptor L2
APLP2 amyloid beta (A4) precursor-like protein 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CA12 carbonic anhydrase XII
CD93 CD93 molecule
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
GJA1 gap junction protein, alpha 1, 43kDa
HAT1 histone acetyltransferase 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LBH limb bud and heart development
LBR lamin B receptor
MAOA monoamine oxidase A
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
NOTCH3 notch 3
NUSAP1 nucleolar and spindle associated protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PCGF2 polycomb group ring finger 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PODXL podocalyxin-like
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SOSTDC1 sclerostin domain containing 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THSD7A thrombospondin, type I, domain containing 7A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
WT1 Wilms tumor 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZMYND8 zinc finger, MYND-type containing 8