BRD-K10705233_GW405833 hydrochloride_SKM1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_SKM1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AEBP1 AE binding protein 1
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP2A charged multivesicular body protein 2A
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FKBP11 FK506 binding protein 11, 19 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXD1 homeobox D1
IFITM1 interferon induced transmembrane protein 1
KLF6 Kruppel-like factor 6
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MCOLN1 mucolipin 1
MERTK MER proto-oncogene, tyrosine kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1D myosin ID
NPY1R neuropeptide Y receptor Y1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PRKD3 protein kinase D3
QPCT glutaminyl-peptide cyclotransferase
RCAN1 regulator of calcineurin 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF144A ring finger protein 144A
RRAGD Ras-related GTP binding D
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UGP2 UDP-glucose pyrophosphorylase 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AOX1 aldehyde oxidase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
C3 complement component 3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL19 chemokine (C-C motif) ligand 19
CD24 CD24 molecule
COL4A5 collagen, type IV, alpha 5
CORO1A coronin, actin binding protein, 1A
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FLRT2 fibronectin leucine rich transmembrane protein 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GZMK granzyme K (granzyme 3; tryptase II)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
LY86 lymphocyte antigen 86
MAMLD1 mastermind-like domain containing 1
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSLN mesothelin
MYBPC1 myosin binding protein C, slow type
NUP85 nucleoporin 85kDa
PAM peptidylglycine alpha-amidating monooxygenase
PEG3 paternally expressed 3
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLAC8 placenta-specific 8
PODXL podocalyxin-like
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNF167 ring finger protein 167
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SLC25A46 solute carrier family 25, member 46
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TM4SF1 transmembrane 4 L six family member 1
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
WNT5A wingless-type MMTV integration site family, member 5A
ZNF185 zinc finger protein 185 (LIM domain)