BRD-K10705233_GW405833 hydrochloride_PL21_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_PL21_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPA aspartoacylase
ATF5 activating transcription factor 5
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BEX1 brain expressed, X-linked 1
BGN biglycan
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCPG1 cell cycle progression 1
CD38 CD38 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CLGN calmegin
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTH cystathionine gamma-lyase
CXCL11 chemokine (C-X-C motif) ligand 11
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ELOVL5 ELOVL fatty acid elongase 5
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FOSL2 FOS-like antigen 2
FTL ferritin, light polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA13 heat shock protein 70kDa family, member 13
IDO1 indoleamine 2,3-dioxygenase 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MFSD10 major facilitator superfamily domain containing 10
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NKG7 natural killer cell granule protein 7
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLSCR4 phospholipid scramblase 4
PMP22 peripheral myelin protein 22
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVRL3 poliovirus receptor-related 3
RB1CC1 RB1-inducible coiled-coil 1
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC63 SEC63 homolog (S. cerevisiae)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLA Src-like-adaptor
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRGN serglycin
STAMBP STAM binding protein
STC2 stanniocalcin 2
TBC1D31 TBC1 domain family, member 31
TCEA1 transcription elongation factor A (SII), 1
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADRB2 adrenoceptor beta 2, surface
BCHE butyrylcholinesterase
CDC42 cell division cycle 42
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CTSZ cathepsin Z
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DERA deoxyribose-phosphate aldolase (putative)
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F12 coagulation factor XII (Hageman factor)
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
LGMN legumain
LMNB1 lamin B1
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYST lysosomal trafficking regulator
MPZL2 myelin protein zero-like 2
MTA1 metastasis associated 1
MYO6 myosin VI
NT5DC2 5'-nucleotidase domain containing 2
PODXL podocalyxin-like
RAD23B RAD23 homolog B (S. cerevisiae)
RASA4 RAS p21 protein activator 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX11 SRY (sex determining region Y)-box 11
TAGLN2 transgelin 2
TERT telomerase reverse transcriptase
TRIM14 tripartite motif containing 14