BRD-K10705233_GW405833 hydrochloride_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
AGR2 anterior gradient 2
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
AREG amphiregulin
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
BZW2 basic leucine zipper and W2 domains 2
CBS cystathionine-beta-synthase
CCDC85B coiled-coil domain containing 85B
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EFS embryonal Fyn-associated substrate
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDPS farnesyl diphosphate synthase
FKBP11 FK506 binding protein 11, 19 kDa
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGHM immunoglobulin heavy constant mu
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ITGB5 integrin, beta 5
KRT20 keratin 20, type I
LDLR low density lipoprotein receptor
MAST2 microtubule associated serine/threonine kinase 2
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NSDHL NAD(P) dependent steroid dehydrogenase-like
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
REG1A regenerating islet-derived 1 alpha
RHOQ ras homolog family member Q
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRED2 sprouty-related, EVH1 domain containing 2
SQLE squalene epoxidase
SQRDL sulfide quinone reductase-like (yeast)
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM2 tripartite motif containing 2
UPP1 uridine phosphorylase 1
VCAN versican
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
CAV2 caveolin 2
CD93 CD93 molecule
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FZD6 frizzled class receptor 6
GIMAP4 GTPase, IMAP family member 4
H2AFX H2A histone family, member X
HPRT1 hypoxanthine phosphoribosyltransferase 1
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
MEF2C myocyte enhancer factor 2C
MYOF myoferlin
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TFRC transferrin receptor
TGM2 transglutaminase 2
WWTR1 WW domain containing transcription regulator 1
ZW10 zw10 kinetochore protein