BRD-K10705233_GW405833 hydrochloride_MCF7_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_MCF7_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CRY1 cryptochrome circadian clock 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
FST follistatin
FZD7 frizzled class receptor 7
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFRD1 interferon-related developmental regulator 1
IGFBP4 insulin-like growth factor binding protein 4
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT20 keratin 20, type I
MALL mal, T-cell differentiation protein-like
MBNL2 muscleblind-like splicing regulator 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
CDC25A cell division cycle 25A
CRISP3 cysteine-rich secretory protein 3
GATA2 GATA binding protein 2
KIF14 kinesin family member 14
NCALD neurocalcin delta
PPIF peptidylprolyl isomerase F
RAD23B RAD23 homolog B (S. cerevisiae)
RGS4 regulator of G-protein signaling 4
SESN1 sestrin 1
TCF4 transcription factor 4
TNS1 tensin 1