BRD-K10705233_GW405833 hydrochloride_MCF7_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_MCF7_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CD8A CD8a molecule
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN1 claudin 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
GCLC glutamate-cysteine ligase, catalytic subunit
IFI16 interferon, gamma-inducible protein 16
JAG1 jagged 1
KRT81 keratin 81, type II
MAN2A1 mannosidase, alpha, class 2A, member 1
MX1 MX dynamin-like GTPase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP2 epithelial membrane protein 2
EVL Enah/Vasp-like
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
MCM6 minichromosome maintenance complex component 6
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein