BRD-K10705233_GW405833 hydrochloride_LOVO_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_LOVO_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ARF1 ADP-ribosylation factor 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CTH cystathionine gamma-lyase
CTSA cathepsin A
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFS embryonal Fyn-associated substrate
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
FAM129A family with sequence similarity 129, member A
FBXO7 F-box protein 7
FHL2 four and a half LIM domains 2
FRS2 fibroblast growth factor receptor substrate 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
IL6ST interleukin 6 signal transducer
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MARS methionyl-tRNA synthetase
MCOLN1 mucolipin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MXI1 MAX interactor 1, dimerization protein
NCF4 neutrophil cytosolic factor 4, 40kDa
NFIL3 nuclear factor, interleukin 3 regulated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKCQ protein kinase C, theta
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAD23B RAD23 homolog B (S. cerevisiae)
SLC16A6 solute carrier family 16, member 6
SLC44A4 solute carrier family 44, member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TBX3 T-box 3
TESC tescalcin
TFF1 trefoil factor 1
TRBC1 T cell receptor beta constant 1
TSPAN1 tetraspanin 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
ATP11B ATPase, class VI, type 11B
C3 complement component 3
CD24 CD24 molecule
CDC20 cell division cycle 20
CFD complement factor D (adipsin)
CLCA2 chloride channel accessory 2
CSTA cystatin A (stefin A)
DPYD dihydropyrimidine dehydrogenase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXT1 exostosin glycosyltransferase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GJA1 gap junction protein, alpha 1, 43kDa
HOPX HOP homeobox
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
MT1E metallothionein 1E
MT1X metallothionein 1X
MT2A metallothionein 2A
OSBPL10 oxysterol binding protein-like 10
PEG10 paternally expressed 10
PKM pyruvate kinase, muscle
PPL periplakin
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SRGN serglycin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMSB15B thymosin beta 15B
TNS3 tensin 3
TXNDC9 thioredoxin domain containing 9
ZNF544 zinc finger protein 544
ZNF586 zinc finger protein 586