BRD-K10705233_GW405833 hydrochloride_HT115_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_HT115_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
CSTA cystatin A (stefin A)
CXCL11 chemokine (C-X-C motif) ligand 11
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR2 early growth response 2
EGR3 early growth response 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GNAS GNAS complex locus
GREB1 growth regulation by estrogen in breast cancer 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER2 homer scaffolding protein 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KYNU kynureninase
LUM lumican
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MAP2K3 mitogen-activated protein kinase kinase 3
MGP matrix Gla protein
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
NID1 nidogen 1
NPY1R neuropeptide Y receptor Y1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGN osteoglycin
OMD osteomodulin
OPN3 opsin 3
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
POSTN periostin, osteoblast specific factor
PPOX protoporphyrinogen oxidase
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
SELE selectin E
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TENM1 teneurin transmembrane protein 1
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ANGPT1 angiopoietin 1
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
C14ORF2 chromosome 14 open reading frame 2
C1ORF54 chromosome 1 open reading frame 54
CA12 carbonic anhydrase XII
CCNF cyclin F
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CKAP2 cytoskeleton associated protein 2
CLDN10 claudin 10
DEFB1 defensin, beta 1
FGFR3 fibroblast growth factor receptor 3
GATA2 GATA binding protein 2
GMNN geminin, DNA replication inhibitor
HOXA10 homeobox A10
IGFBP4 insulin-like growth factor binding protein 4
KIF20A kinesin family member 20A
LY75 lymphocyte antigen 75
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MECOM MDS1 and EVI1 complex locus
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MRPS16 mitochondrial ribosomal protein S16
PLAGL1 pleiomorphic adenoma gene-like 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKD3 protein kinase D3
PRODH proline dehydrogenase (oxidase) 1
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RRP1B ribosomal RNA processing 1B
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
STOM stomatin
SYPL1 synaptophysin-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN3 tetraspanin 3