BRD-K10705233_GW405833 hydrochloride_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CHIC2 cysteine-rich hydrophobic domain 2
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUOX2 dual oxidase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INHBA inhibin, beta A
KLF4 Kruppel-like factor 4 (gut)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TFF3 trefoil factor 3 (intestinal)
THBD thrombomodulin
TLR4 toll-like receptor 4
TRIB3 tribbles pseudokinase 3
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ASS1 argininosuccinate synthase 1
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRABP2 cellular retinoic acid binding protein 2
DENND2D DENN/MADD domain containing 2D
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
HP haptoglobin
HSPB1 heat shock 27kDa protein 1
IL17RB interleukin 17 receptor B
ITGB1BP1 integrin beta 1 binding protein 1
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
LARP1 La ribonucleoprotein domain family, member 1
LUM lumican
LXN latexin
MCM3 minichromosome maintenance complex component 3
MFAP3L microfibrillar-associated protein 3-like
MUC16 mucin 16, cell surface associated
NVL nuclear VCP-like
OSBPL10 oxysterol binding protein-like 10
OXA1L oxidase (cytochrome c) assembly 1-like
PEG10 paternally expressed 10
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RRM2 ribonucleotide reductase M2
SLPI secretory leukocyte peptidase inhibitor
TFRC transferrin receptor
TRIB2 tribbles pseudokinase 2
TUBB tubulin, beta class I