BRD-K10705233_GW405833 hydrochloride_HCT116_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_HCT116_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CCR7 chemokine (C-C motif) receptor 7
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
COL14A1 collagen, type XIV, alpha 1
COL3A1 collagen, type III, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FPGS folylpolyglutamate synthase
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTPBP2 GTP binding protein 2
HBB hemoglobin, beta
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFITM3 interferon induced transmembrane protein 3
IL6 interleukin 6
INHBE inhibin, beta E
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5D lysine (K)-specific demethylase 5D
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
KYNU kynureninase
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
LXN latexin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS3P1 Meis homeobox 3 pseudogene 1
MGP matrix Gla protein
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRL platelet-derived growth factor receptor-like
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTPRO protein tyrosine phosphatase, receptor type, O
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SRGN serglycin
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
THBS2 thrombospondin 2
TKT transketolase
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALDOA aldolase A, fructose-bisphosphate
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CCNE2 cyclin E2
CD1E CD1e molecule
CDC25A cell division cycle 25A
CKB creatine kinase, brain
CPA3 carboxypeptidase A3 (mast cell)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYTL1 cytokine-like 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIC2 hypermethylated in cancer 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INTS3 integrator complex subunit 3
ITGB1BP1 integrin beta 1 binding protein 1
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MYB v-myb avian myeloblastosis viral oncogene homolog
RRP1B ribosomal RNA processing 1B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TNS3 tensin 3
XIST X inactive specific transcript (non-protein coding)
ZDHHC6 zinc finger, DHHC-type containing 6
ZFP36L2 ZFP36 ring finger protein-like 2