BRD-K10705233_GW405833 hydrochloride_A549_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_A549_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
AKAP12 A kinase (PRKA) anchor protein 12
AMDHD2 amidohydrolase domain containing 2
ANK2 ankyrin 2, neuronal
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BZW2 basic leucine zipper and W2 domains 2
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYM crystallin, mu
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
ELOVL5 ELOVL fatty acid elongase 5
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV1 ets variant 1
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GK glycerol kinase
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MOCOS molybdenum cofactor sulfurase
MSMO1 methylsterol monooxygenase 1
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK5 proprotein convertase subtilisin/kexin type 5
PFDN2 prefoldin subunit 2
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
RGS2 regulator of G-protein signaling 2
RIPK2 receptor-interacting serine-threonine kinase 2
RRAD Ras-related associated with diabetes
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VCAN versican
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF5 activating transcription factor 5
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
B3GNT1
BCHE butyrylcholinesterase
BLCAP bladder cancer associated protein
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CCND3 cyclin D3
CCNF cyclin F
CD163 CD163 molecule
CDC25A cell division cycle 25A
DERA deoxyribose-phosphate aldolase (putative)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FASTKD1 FAST kinase domains 1
FCGBP Fc fragment of IgG binding protein
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HDAC2 histone deacetylase 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MMP9 matrix metallopeptidase 9
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PODXL podocalyxin-like
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RAB4A RAB4A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RRP1B ribosomal RNA processing 1B
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SNCAIP synuclein, alpha interacting protein
SNX6 sorting nexin 6
SOX11 SRY (sex determining region Y)-box 11
TMEM168 transmembrane protein 168
TMEM2 transmembrane protein 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TSPAN4 tetraspanin 4
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WRB tryptophan rich basic protein
ZC3HAV1 zinc finger CCCH-type, antiviral 1