BRD-K10705233_GW405833 hydrochloride_A375_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_A375_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK2 ankyrin 2, neuronal
ATF3 activating transcription factor 3
CHIC2 cysteine-rich hydrophobic domain 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MMP1 matrix metallopeptidase 1
NANS N-acetylneuraminic acid synthase
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PYCR1 pyrroline-5-carboxylate reductase 1
RABAC1 Rab acceptor 1 (prenylated)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TFF1 trefoil factor 1
TRIB3 tribbles pseudokinase 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AURKA aurora kinase A
B3GNT1
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CLU clusterin
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
ICMT isoprenylcysteine carboxyl methyltransferase
KLK11 kallikrein-related peptidase 11
MDFIC MyoD family inhibitor domain containing
PRSS23 protease, serine, 23